Telecharger Win Xp Fr Isosorbide
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| Clinical data | |
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| AHFS/Drugs.com | Monograph |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Bioavailability | >95% |
| Protein binding | <5% |
| Metabolism | Hepatic |
| Elimination half-life | 5 hours |
| Excretion | Kidney (93%) |
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| Chemical and physical data | |
| Formula | C6H9NO6 |
| Molar mass | 191.139 g/mol g·mol−1 |
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Isosorbide mononitrate, sold under many brand names, is a medication used for heart related chest pain (angina), heart failure, and esophageal spasms.[1] It can be used both to treat and to prevent heart related chest pain, however is generally less preferred than beta blockers or calcium channel blockers.[1] It is taken by mouth.[1]
Common side effects include headache, low blood pressure with standing, blurry vision, and skin flushing.[1] Serious side effects may include low blood pressure especially if also exposed to PDE5 inhibitors such as sildenafil.[1] Use is not recommended in pregnancy.[2] It is believed to work by relaxing smooth muscle within blood vessels.[1]
It was patented in 1971 and approved for medical use in 1981.[3] It is available as a generic medication.[2] A month supply in the United Kingdom costs the NHS about one £ per month as of 2019.[2] In the United States the wholesale cost of this amount is about US$4.30.[4] In 2016 it was the 101st most prescribed medication in the United States with more than 7 million prescriptions.[5]
Medical uses[edit]
Isosorbide mononitrate is a nitrate-class drug used for the prevention of angina pectoris.
Adverse effects[edit]
The following adverse effects have been reported in studies with isosorbide mononitrate:
Very common: Headache predominates (up to 30%) necessitating withdrawal of 2 to 3% of patients, but the incidence reduces rapidly as treatment continues.
Common: Tiredness, sleep disturbances (6%) and gastrointestinal disturbances (6%) have been reported during clinical trials with isosorbide mononitrate modified-release tablets, but at a frequency no greater than for placebo. Hypotension (4 to 5%), poor appetite (2.5%), nausea (1%).
Adverse effects associated with the clinical use of the drug are as expected with all nitrate preparations. They occur mainly in the early stages of treatment.
Hypotension (4%) with symptoms such as dizziness and nausea (1%) have been reported. In general, these symptoms disappear during long-term treatment.
Other reactions that have been reported with isosorbide mononitrate modified-release tablets include tachycardia, vomiting, diarrhoea, vertigo, and heartburn.
Interactions[edit]
- Sildenafil (Viagra). Concomitant administration of isosorbide mononitrate and sildenafil (Viagra) or other phosphodiesterase inhibitors (Tadalafil and Udenafil) can potentiate the vasodilatory effect of isosorbide mononitrate with the potential result of serious side-effects such as syncope or myocardial infarction. Life-threatening hypotension may also occur. Therefore, sildenafil should not be given to patients already receiving isosorbide mononitrate therapy.
- Sulfhydryl-containing compounds. The metabolism of organic nitrates to nitric oxide is dependent on the presence of sulfhydryl groups in the muscle. The combination of oral N-acetylcysteine and a single dose of sustained-release isosorbide mononitrate 60 mg significantly prolonged the total exercise time in patients with angina pectoris and angiographically proven significant coronary artery disease, when compared with isosorbide mononitrate alone. Concomitant administration of other exogenous sources of sulfhydryl groups such as methionine and captopril may produce a similar interaction.
- Phenylalkylamine calcium antagonists. The addition of a calcium channel blocker of the verapamil type, such as gallopamil 75 mg, has been shown to further improve left ventricular functional parameters when given in combination with isosorbide mononitrate in a sustained-release formulation.
- Propranolol. The addition of isosorbide mononitrate to propranolol treatment in patients with cirrhosis and portal hypertension caused a marked fall in portal pressure, a reduction in hepatic blood flow, cardiac output and mean arterial blood pressure, but no additional change in azygos blood flow. The additional effect of isosorbide mononitrate was especially evident in patients whose portal pressure was not reduced by propranolol.
- Calcium antagonists (general). Marked symptomatic orthostatic hypotension has been reported when calcium antagonists and organic nitrates were used in combination. Dose adjustments of either class of agent may be necessary.
Brand names[edit]
It is sold in the US by Kremers Urban under the trade name Monoket, also sold in the US under the name Imdur, and marketed in the UK under the trade names: Isotard, Monosorb, Chemydur. In India, this drug is available under the brand names of Ismo, Imdur,Isonorm, Monotrate, Solotrate, and Monit. In Russia it is occasionally used under the brand names Monocinque and Pektrol. In Australia, this drug is available under the brand name Duride.
References[edit]
Telecharger Win Xp Fr Isosorbide 1
- ^ abcdef'Isosorbide Dinitrate/Mononitrate Monograph for Professionals'. Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
- ^ abcBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 219–220. ISBN9780857113382.
- ^Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 454. ISBN9783527607495.
- ^'NADAC as of 2019-02-27'. Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
- ^'The Top 300 of 2019'. clincalc.com. Retrieved 22 December 2018.
External links[edit]
David Wheeler, Managing Director of RBC Group, and Diccon Grayling, Macro 4 Partner Manager, shake hands on a strategic partnership in Australia and New Zealand.
Integrated offering will automate processes and workflow surrounding inbound and outbound documents and data
Macro 4, a division of UNICOM Global, is announcing a new strategic partnership with RBC Business Solutions Pty Ltd in Australia. Under the agreement, the Australian company will integrate Macro 4’s technology to create a complete business process automation solution that will be offered to its existing and new customers throughout Australia and New Zealand.
RBC Group, one of Australia’s largest independent and privately owned technology integrators, will integrate Macro 4’s Columbus enterprise information management (EIM) suite into its own docs2me business automation platform, a cloud-native, end-to-end application that automates the flow of work to optimize a variety of business processes.
David Wheeler, RBC Group Managing Director, says, 'This is a major step for RBC Group as we expand our technology platform in the Asia Pacific Region. This partnership will allow our customers to take control of their data and control the document lifecycle, providing them with efficiency and security benefits.”
Telecharger Win Xp Fr Isosorbide Side Effects
Docs2me delivers document and workflow automation that is easy to implement, configure, use and modify. Its automation capabilities increase productivity, shorten cycle times, improve compliance and control critical corporate content. Columbus will add the capability to capture, manage and deliver a wider range of enterprise content – such as outbound bills, statements and correspondence – as well as creating personalized documents at volume.
Luke Bartlett, RBC Solutions Director, says, “We are excited about how Columbus will augment and extend the RBC business automation platform. It will allow us to offer customers an automated business process solution that streamlines processes and workflow around outbound documents and data as well as inbound documents throughout the entire business process and customer communications cycle. Columbus provides an easy way for us to deliver electronic presentment via the web, email and mobile devices, as well as compliant document retention and information lifecycle management. All of this comes with the reassurance that we’re working with a truly scalable and globally proven solution.”
Columbus, Macro 4’s cross-platform EIM suite, enables companies to implement digital transformation initiatives quickly, personalize customer communications and unlock the value of their corporate content. The Columbus suite encompasses enterprise content management, output management, intelligent document composition and embedded business intelligence. A non-invasive solution, requiring no changes to existing applications, Columbus provides a fast and painless implementation timeline and ROI realization.
Diccon Grayling, Macro 4 Partner Manager, says, “The strategic partnership with such a high profile and established company as RBC Group presents a fantastic opportunity for both parties. This is one of those occasions where there is perfect alignment between two companies in the same market – each bringing their own set of skills, knowledge, solutions and expertise to combine to offer the customer a truly exceptional and very relevant business solution.”
About RBC Group www.rbcgroup.com.au
RBC Group is one of Australia’s largest independent and privately owned technology integrators with a large market penetration, founded from its core business as a print and imaging solutions company. Formed in 1975 by Geoff Layton, RBC Group is in its 42nd year of operation and is 100% Australian owned and operated.
A shared vision to help businesses reduce the cost and hassle of document output management has evolved into the company’s current portfolio, which includes IT infrastructure, cloud hosting and a complete managed service. This holistic portfolio showcases RBC Group’s focus on optimizing consumables, service, IT administration and financing, all of which lead to a more streamlined and cost effective operational structure.
Today, RBC Group has emerged to become one of the fastest growing and most successful businesses in Australia with consistent year on year growth. The company currently provides managed services to over 3,000 clients nationally, comprising both hardware and software solutions, as well as maintaining billions of prints and associated devices.
About Macro 4 www.macro4.com
Macro 4, a division of UNICOM Global, develops software solutions that accelerate business transformation. Macro 4’s cross-platform enterprise information management solutions make it easy for companies to go digital, personalize customer communications and unlock the value of their corporate content. Macro 4 solutions for application lifecycle management, session management and performance optimization are used by many of the world’s largest enterprises to modernize their mainframe applications and development processes.
About UNICOM® Global www.unicomglobal.com
UNICOM Global consists of more than forty (40) corporate entities encompassing a wide range of businesses across all geographic regions. With its corporate headquarters in Los Angeles, California, to offices in Illinois, Kentucky, Florida, Massachusetts, Maryland, Minnesota, New Hampshire, North Carolina, New Jersey, New York, Texas and Virginia, throughout EMEA in the UK, Ireland, Germany, France, Italy, Spain, Denmark, Belgium, Switzerland and the UAE, and across Asia/Pacific with locations in Japan, China, India, Australia, Korea, Thailand, Taiwan and the Philippines. UNICOM Global offers deep in-house resources and flexible IT solutions to partners worldwide, and is continually focused on acquiring and integrating mature and growing mid-cap NASDAQ, London Stock Exchange AIM and German publically-traded companies in technology, financing, IT, real estate, and business services. Visit UNICOM’s websites for additional information about the services, products and solutions that the Company offers:
unicomglobal.com UNICOM Global - Parent organization for all UNICOM entities
unicomsi.com UNICOM Systems - Enterprise Automation and Performance Solutions unicomgov.com UNICOM Government (formerly NASDAQ: GTSI) - Government IT solutions unicomengineering.com UNICOM Engineering (formerly NASDAQ: NEI) - Purpose-built appliance platforms
unicom.org UNICOM Science and Technology Parks
unicom-capital.com UNICOM Capital - Business and Financial Services
solidDB.com solidDB - In-memory relational database management system
usrobotics.com USRobotics.com - Portal for IoT, Cloud Computing and Communications Divisions
memeo.com Memeo - Enterprise-grade Secure File Sharing for the Cloud
firetide.com Firetide - Safety and Security Solutions through wireless products
detec.com DETEC - Document composition products
softlanding.com SoftLanding Systems - IBM i and Power platform software products
macro4.com Macro 4 (formerly LONDON: MAO) - Document and Application Management
illustro.com illustro - Modernization enabling software solutions
iet-solutions.com iET Solutions - ITIL ITSM software solutions
eden.com Eden - Portal for Business and Financial Services, Real Estate and Financing
cics.com CICS.com - Portal for UNICOM’s Enterprise Software Divisions
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For further information please contact lbartlett@rbc.com.au or diccon.grayling@macro4.com